They are significant in art history, as the artist had more freedom from iconographic conventions than in the main panel as they could only be seen ...
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from close up. As the main panels themselves became larger and more dramatic, predellas fell from use around 1510-20 in the High Renaissance, although older or more conservative painters continued to use them, for example Luca Signorelli, by then in his 70s, in about 1521. In this case he is thought to have only done the underdrawing for the main scene, leaving the painting to his workshop assistants. But he is thought to have painted the predella scenes himself.
